WO2005076819A3 - Chlorite in the treatment of neurodegenerative disease - Google Patents

Chlorite in the treatment of neurodegenerative disease Download PDF

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Publication number
WO2005076819A3
WO2005076819A3 PCT/US2005/002469 US2005002469W WO2005076819A3 WO 2005076819 A3 WO2005076819 A3 WO 2005076819A3 US 2005002469 W US2005002469 W US 2005002469W WO 2005076819 A3 WO2005076819 A3 WO 2005076819A3
Authority
WO
WIPO (PCT)
Prior art keywords
neurodegenerative disease
chlorite
treatment
cell activation
immune cell
Prior art date
Application number
PCT/US2005/002469
Other languages
French (fr)
Other versions
WO2005076819A2 (en
Inventor
Michael S Mcgrath
Original Assignee
Univ California
Michael S Mcgrath
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34860199&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2005076819(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ California, Michael S Mcgrath filed Critical Univ California
Priority to CN2005800037236A priority Critical patent/CN101102781B/en
Priority to AU2005213300A priority patent/AU2005213300B2/en
Priority to CA2554511A priority patent/CA2554511C/en
Priority to EP05722556.7A priority patent/EP1711191B1/en
Priority to JP2006552151A priority patent/JP5072367B2/en
Publication of WO2005076819A2 publication Critical patent/WO2005076819A2/en
Publication of WO2005076819A3 publication Critical patent/WO2005076819A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/20—Elemental chlorine; Inorganic compounds releasing chlorine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/40—Peroxides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Abstract

The invention features methods of treating a macrophage-associated neurodegenerative disease such as amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD), or multiple sclerosis (MS) in a subject by administering chlorite in an amount effective to decrease blood immune cell activation. The invention also features methods of monitoring therapy by assessing blood immune cell activation before and after therapy.
PCT/US2005/002469 2004-02-03 2005-01-25 Chlorite in the treatment of neurodegenerative disease WO2005076819A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CN2005800037236A CN101102781B (en) 2004-02-03 2005-01-25 Chlorite in the treatment of neurodegenerative disease
AU2005213300A AU2005213300B2 (en) 2004-02-03 2005-01-25 Chlorite in the treatment of neurodegenerative disease
CA2554511A CA2554511C (en) 2004-02-03 2005-01-25 Chlorite in the treatment of neurodegenerative disease
EP05722556.7A EP1711191B1 (en) 2004-02-03 2005-01-25 Chlorite in the treatment of amyotrophic lateral sclerosis
JP2006552151A JP5072367B2 (en) 2004-02-03 2005-01-25 Chlorous acid in the treatment of neurodegenerative diseases

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US54157604P 2004-02-03 2004-02-03
US60/541,576 2004-02-03

Publications (2)

Publication Number Publication Date
WO2005076819A2 WO2005076819A2 (en) 2005-08-25
WO2005076819A3 true WO2005076819A3 (en) 2006-04-13

Family

ID=34860199

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/002469 WO2005076819A2 (en) 2004-02-03 2005-01-25 Chlorite in the treatment of neurodegenerative disease

Country Status (7)

Country Link
US (5) US7105183B2 (en)
EP (2) EP1711191B1 (en)
JP (3) JP5072367B2 (en)
CN (2) CN102423318B (en)
AU (1) AU2005213300B2 (en)
CA (2) CA2838392C (en)
WO (1) WO2005076819A2 (en)

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JP2005510524A (en) * 2001-11-16 2005-04-21 アルス・セラピー・デベロツプメント・フアンデーシヨン・インコーポレーテツド Treatment of neurodegenerative disorders by modulating the polyamine pathway
US7105183B2 (en) * 2004-02-03 2006-09-12 The Regents Of The University Of California Chlorite in the treatment of neurodegenerative disease
EP1810030A1 (en) * 2004-07-16 2007-07-25 Gyros Patent Ab Sequential method
NZ564141A (en) 2005-05-09 2011-02-25 Theranos Inc Two way communication system for monitoring an analyte
JP5645361B2 (en) * 2005-08-02 2014-12-24 エクスバイオテク インコーポレーティッド Diagnosis, treatment and prevention of vascular disorders using IL-1α autoantibodies
EP1979269A4 (en) 2005-12-22 2013-01-02 Taiji Biomedical Inc Chlorite formulations, and methods of preparation and use thereof
AU2013234421B2 (en) * 2005-12-22 2015-08-27 Neuraltus Pharmaceuticals, Inc. Chlorite formulations, and methods of preparation and use thereof
US11287421B2 (en) 2006-03-24 2022-03-29 Labrador Diagnostics Llc Systems and methods of sample processing and fluid control in a fluidic system
US8741230B2 (en) 2006-03-24 2014-06-03 Theranos, Inc. Systems and methods of sample processing and fluid control in a fluidic system
US8007999B2 (en) 2006-05-10 2011-08-30 Theranos, Inc. Real-time detection of influenza virus
US20110008282A1 (en) * 2006-05-15 2011-01-13 Xbiotech, Inc. IL-1alpha immunization induces autoantibodies protective against atherosclerosis
PL2109623T3 (en) * 2006-05-22 2012-03-30 Xbiotech Inc Treatment of cancer with anti-il-1 antibodies
US20080113391A1 (en) 2006-11-14 2008-05-15 Ian Gibbons Detection and quantification of analytes in bodily fluids
FR2910811B1 (en) * 2007-01-03 2009-07-10 Ass Pour Le Dev De La Biothera USE OF RILUZOLE AND ITS DERIVATIVES FOR MANUFACTURING NEW DRUGS
US8158430B1 (en) 2007-08-06 2012-04-17 Theranos, Inc. Systems and methods of fluidic sample processing
ES2797126T3 (en) * 2008-05-30 2020-12-01 Xbiotech Inc IL-1 alpha antibody uses
CN102209557A (en) * 2008-09-12 2011-10-05 埃克斯生物科技公司 Targeting pathogenic monocytes
EA201290041A1 (en) * 2009-08-06 2012-07-30 Ньюралтус Фармасьютикалс, Инк. TREATMENT OF DISORDERS ASSOCIATED WITH MACROPHAGES
MX2012004620A (en) 2009-10-19 2012-06-25 Theranos Inc Integrated health data capture and analysis system.
US20130230499A1 (en) * 2010-03-10 2013-09-05 Michal Eisenbach-Schwartz Cellular blood markers for early diagnosis of als and for als progression
US20110311547A1 (en) 2010-06-18 2011-12-22 Xbiotech, Inc. Arthritis Treatment
EP2605771B1 (en) * 2010-08-16 2018-04-04 Allergan, Inc. Method of activating regulatory t cells with alpha-2b adrenergic receptor agonists
EP2608808B1 (en) 2010-08-23 2017-01-18 XBiotech, Inc Treatment for neoplastic diseases
US9724409B2 (en) 2011-04-01 2017-08-08 Xbiotech, Inc. Treatment of inflammatory skin disease
RU2622021C2 (en) 2011-09-23 2017-06-08 ИксБиотеч, Инк. Cachexia therapy
WO2013093891A1 (en) 2011-12-22 2013-06-27 Nuvo Research Gmbh Liposomal chlorite or chlorate compositions
RU2718751C2 (en) * 2012-08-31 2020-04-14 Файв Прайм Терапьютикс, Инк. Methods of treating pathological conditions with antibodies which bind to the colony-stimulating factor 1 receptor (csf1r)
US9545441B2 (en) 2012-09-18 2017-01-17 Xbiotech, Inc. Treatment of diabetes
CA2945179A1 (en) * 2014-05-16 2015-11-19 Michael S. Mcgrath Methods and compositions for treatment of macrophage-related disorders
EP3072513A1 (en) * 2015-03-26 2016-09-28 Medday Biotin for treating Amyotrophic lateral sclerosis
WO2017079161A2 (en) * 2015-11-02 2017-05-11 Neuraltus Pharmaceuticals, Inc. Treatment of neurodegenerative disease with sodium chlorite
KR20190117579A (en) 2017-02-16 2019-10-16 엑스바이오테크, 인크. Treatment of purulent hanitis
JP7119017B2 (en) 2020-03-13 2022-08-16 本田技研工業株式会社 Straddle-type electric vehicle
US20230390331A1 (en) * 2022-05-19 2023-12-07 Neuvivo, Inc. Biomarkers For Neurogenerative Disease

Citations (1)

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US4725437A (en) * 1985-05-02 1988-02-16 Oxo Chemie Gmbh Aqueous chlorite matrix solution

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Also Published As

Publication number Publication date
WO2005076819A2 (en) 2005-08-25
US20110053186A1 (en) 2011-03-03
CA2838392A1 (en) 2005-08-25
CN101102781B (en) 2012-06-20
AU2005213300A1 (en) 2005-08-25
CA2554511A1 (en) 2005-08-25
EP2574342A1 (en) 2013-04-03
JP5797083B2 (en) 2015-10-21
EP1711191A4 (en) 2008-12-17
JP2012067110A (en) 2012-04-05
AU2005213300B2 (en) 2011-06-16
US20170065634A1 (en) 2017-03-09
EP1711191B1 (en) 2014-03-19
CA2838392C (en) 2017-04-04
US20060159775A1 (en) 2006-07-20
CN101102781A (en) 2008-01-09
JP2015205901A (en) 2015-11-19
JP5072367B2 (en) 2012-11-14
US20050181068A1 (en) 2005-08-18
JP2007520554A (en) 2007-07-26
EP1711191A2 (en) 2006-10-18
US9364501B2 (en) 2016-06-14
CA2554511C (en) 2016-01-19
US7105183B2 (en) 2006-09-12
CN102423318A (en) 2012-04-25
US20120295296A1 (en) 2012-11-22
EP2574342B1 (en) 2018-03-07
CN102423318B (en) 2015-09-09
US8029826B2 (en) 2011-10-04

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